ChemicalBook CAS DataBase List (R)-2-Benzylsuccinic acid

(R)-2-Benzylsuccinic acid synthesis

10synthesis methods

Product Name:(R)-2-Benzylsuccinic acid
CAS Number:21307-97-1
Molecular formula:C11H12O4
Molecular Weight:208.21

6540-96-1 Synthesis

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21307-97-1
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Yield:-

Steps:

Multi-step reaction with 6 steps
1.1: oxalyl chloride / CH₂Cl₂ / 2 h / Heating
2.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C
2.2: 43 percent / tetrahydrofuran; hexane / 0.5 h / -78 °C
3.1: n-BuLi / tetrahydrofuran; hexane / 1 h / 0 °C
3.2: 84 percent / tetrahydrofuran; hexane / 0.5 h / -78 °C
4.1: O₃ / methanol / 0.5 h / -10 °C
4.2: 60 percent / thiourea / methanol / 0.92 h / 0 °C
5.1: H₂ / 10 percent Pd/C / methanol / 1 h
5.2: 96 percent / diethyl ether / 20 °C
6.1: 72 percent / aq. sodium chlorite; sodium dihydrogen phosphate; 2-methyl-2-butene / 2-methyl-propan-2-ol / 0.5 h / 20 °C

References:

Kim, Dong H.;Chung, Suhman [Tetrahedron Asymmetry,1999,vol. 10,# 19,p. 3769 - 3776]

65756-81-2 Synthesis