(R)-2-ethylpyrrolidine hydrochloride synthesis
- Product Name:(R)-2-ethylpyrrolidine hydrochloride
- CAS Number:460748-80-5
- Molecular formula:C6H14ClN
- Molecular Weight:135.64
876617-06-0
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460748-80-5
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Yield:-
Reaction Conditions:
with hydrogenchloride in 1,4-dioxane at 20; for 72 h;
Steps:
Add HC1 (23 mL, 4N in 1,4-dioxane, 92 mmol) to a stirred solution of 2R-ethyl-pyrrolidine-1-carboxylic acid tert-butyl ester (2.4 g, 12 mmol) and stir at room temperature for 3 days. Concentrate under reduced pressure to afford the title compound as a colorless solid (1.6 g). *H NMR (CDCI3) 8 9.81 (br s, 1H), 9.18 (br s, 1H), 3.25-3.53 (m, 3H), 1.90-2.21 (m, 6H), 1.03-1.10 (m, 3H).
References:
WO2006/19833,2006,A1 Location in patent:Page/Page column 52
69610-40-8
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460748-80-5
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$235.40/250mg
86661-32-7
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460748-80-5
38 suppliers
$235.40/250mg