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ChemicalBook CAS DataBase List (R)-2-HYDROXYMETHYL-PIPERAZINE-2HCl

(R)-2-HYDROXYMETHYL-PIPERAZINE-2HCl synthesis

3synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: 91 percent / LiAlH4 / tetrahydrofuran / 1.5 h / Heating
2: 56 percent / H2 / 5percent Pd/C / ethanol / 760 Torr

References:

Naylor;Judd;Lloyd;Scopes;Hayes;Birch [Journal of Medicinal Chemistry,1993,vol. 36,# 15,p. 2075 - 2083]