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(R)-2-Methoxymethyl-pyrrolidine hydrochloride synthesis

2synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1.1: 0.83 h / 0 °C
2.1: sodium hydride / tetrahydrofuran / -60 - -50 °C / Inert atmosphere
3.1: potassium hydroxide / water / 20 °C / Inert atmosphere
3.2: Cooling with ice

References:

Enders, Dieter;Fey, Peter;Kipphardt, Helmut [Organic Syntheses,1987,vol. 65,p. 173 - 173]