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(R)-3-Chloro-2-methylpropionyl chloride synthesis

1synthesis methods
-

Yield:80141-50-0 83%

Reaction Conditions:

with 1H-imidazole;thionyl chloride in dichloromethane;0 to 15 deg C, 30 min, then 80 deg C;

References:

Shimazaki;Hasegawa;Kan;et al. [Chemical and Pharmaceutical Bulletin,1982,vol. 30,# 9,p. 3139 - 3146]