(R)-3-Methoxypiperidine hydrochloride synthesis
- Product Name:(R)-3-Methoxypiperidine hydrochloride
- CAS Number:688809-95-2
- Molecular formula:C6H14ClNO
- Molecular Weight:151.6345
745066-86-8
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Yield:-
Reaction Conditions:
with hydrogenchloride;water in dichloromethane at 4; for 1.66667 h;
Steps:
183 Preparation 183: (3R)-3- (methyloxy) piperidine
Preparation 183: (3R)-3- (methyloxy) piperidine A solution of 1,1-dimethylethyl (3R)-3-(methyloxy) piperidine-1-carboxylate (Preparation 182,1. 55 g, 7.2 MMOL) in anhydrous dichloromethane (60 ml) was cooled to 4 C and then saturated with hydrogen choride gas for about 10 min. The reaction mixture was stirred for 1.5 h before concentrating in vauco and azeotroping with anhydrous diethyl ethyl to produce the hydrochloride salt of the title compound as a white hydroscopic solid (0.90 g).
References:
PFIZER LIMITED;PFIZER INC. WO2004/72086, 2004, A2 Location in patent:Page 205