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ChemicalBook CAS DataBase List (R)-(-)-5-OXOTETRAHYDROFURAN-2-CARBOXYLIC ACID

(R)-(-)-5-OXOTETRAHYDROFURAN-2-CARBOXYLIC ACID synthesis

3synthesis methods
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Yield:52 % ee

Reaction Conditions:

with nickel trifluoromethanesulfonate;1,2-bis((2S,5S)-2,5-diphenylphospholan-1-yl)ethane;2,2,2-trifluoroethanol;hydrogen at 65; under 38002.6 Torr; for 24 h;Schlenk technique;Overall yield = 95 percentChromat.; enantioselective reaction;

References:

Deng, Chen-Qiang;Deng, Jin;Fu, Yao;Gan, Li-Jin;Liu, Jiao;Luo, Jia-Hao [Angewandte Chemie - International Edition,2022,vol. 61,# 15,art. no. E202115983][Angew. Chem.,2022,vol. 134,# 15] Location in patent:supporting information

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