(R)-5-phenyl-1,3-dioxolane-2,4-dione synthesis
- Product Name:(R)-5-phenyl-1,3-dioxolane-2,4-dione
- CAS Number:54256-33-6
- Molecular formula:C9H6O4
- Molecular Weight:178.1415
Yield:54256-33-6 99%
Reaction Conditions:
with triethylamine in acetonitrile at 25; for 6 h;Temperature;Solvent;
Steps:
1 Preparation of intermediate I
Under mechanical stirring, add 15.2 g of R-mandelic acid, 22.2 g of triethylamine, 32.5 g of triphosgene 150 mL of acetonitrile to a 250 mL three-necked flask, and react at 25°C for 6 h. The TLC controlled reaction was completed and cooled to room temperature. The mixture was filtered, and the solvent was evaporated in vacuo. After stirring for half an hour, the layers were allowed to stand, the organic phase was dried and concentrated to give a white solid, 17.7 g, Intermediate I, yield 99%.
References:
CN108727212,2018,A Location in patent:Paragraph 0026-0027; 0030; 0033
