(R)-ACETYLAMINO-CYCLOHEXYL-ACETIC ACID synthesis

3synthesis methods

Product Name:(R)-ACETYLAMINO-CYCLOHEXYL-ACETIC ACID
CAS Number:14429-43-7
Molecular formula:C10H17NO3
Molecular Weight:199.25

1,4-Cyclohexadiene-1-acetic acid, α-(acetylamino)-, (αR)-

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14429-43-7
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Yield:14429-43-7 75%

Reaction Conditions:

with hydrogen;platinum(IV) oxide in methanol; for 4 h;

Steps:

4

To a solution of 15g of (R)-(acetylamino)(1,4-cyclohexadiene-l-yl)acetic acid in SOOmL of methanol was added SOOmg of platinum oxide, and the mixture was stirred for 4 hours under hydrogen gas atmosphere. Then, the reaction mixture was filtrated and the filtrate was condensed. The residue was recrystallized from ethanol to give 11.4g (75%) of the title compound.

References:

WO2004/111053,2004,A1 Location in patent:Page/Page column 20

60-35-5 Synthesis