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(R)-(-)-Coniine synthesis

7synthesis methods
1629-58-9 Synthesis
Ethyl vinyl ketone

1629-58-9
124 suppliers
$44.79/5g

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Yield:-

Steps:

Multi-step reaction with 4 steps
1: 79 percent / acetonitrile / Heating
2: 45 percent / 1.) BH3; 2.) 50percent aq. H2SO4 / tetrahydrofuran
3: 47 percent / sodium cyanoborohydride / pH = 3
4: H2 / Pd-C / methanol

References:

Jones;Turner;Howard [Tetrahedron Letters,1993,vol. 34,# 39,p. 6329 - 6332]

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