R-Cyclopropylglycine Methyl ester hydrochloride synthesis

Yield:138326-69-9 93.6%

Reaction Conditions:

with methanol;thionyl chloride at 0; for 0.5 h;

Steps:

59a Preparation of (R)-Amino-cyclopropyl-acetic acid methyl ester

A mixture of BOC-D-cyclopropylglycine (Chem-Impex, Inc., 0.25 g, 1.16 mmol), and methanol (4 mL) was stirred at 25° C., thionyl chloride (0.1 mL, 1.39 mmol) was CAREFULLY added dropwise (cool to 0° C. if larger scale) and stirred an additional 30 minutes until complete by tlc. The mixture was concentrated under reduced pressure to afford a white crystalline solid (180 mg, 93.6%).

References:

US2012/10235,2012,A1 Location in patent:Page/Page column 55