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ChemicalBook CAS DataBase List (R,R,R)-Aprepitant

(R,R,R)-Aprepitant synthesis

1synthesis methods
252742-72-6 Synthesis
5-Chloromethyl-2H-1,2,4-triazolin-3-one

252742-72-6
289 suppliers
$7.00/250mg

(2R,3R)-2-[(1R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine

380499-06-9
15 suppliers
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Yield:1148113-53-4 99%

Reaction Conditions:

with potassium carbonate in water;N,N-dimethyl-formamide at 0;

References:

Gangula, Srinivas;Elati, Chandrashekhar R.;Mudunuru, Satish Varma;Nardela, Anitha;Dongamanti, Ashok;Bhattacharya, Apurba;Bandichhor, Rakeshwar [Synthetic Communications,2010,vol. 40,# 15,p. 2254 - 2268] Location in patent:experimental part

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