ChemicalBook CAS DataBase List (R,R)-Reboxetine

(R,R)-Reboxetine synthesis

10synthesis methods

Product Name:(R,R)-Reboxetine
CAS Number:105017-38-7
Molecular formula:C19H23NO3
Molecular Weight:313.39

94-71-3 Synthesis

94-71-3
313 suppliers
$14.00/5g

(R)-4-Boc-2-((R)-hydroxy(phenyl)Methyl)Morpholine

868685-97-6
8 suppliers
inquiry

105017-38-7
1 suppliers
inquiry

Yield:105017-38-7 84%

Reaction Conditions:

Stage #1: (2R,3R)-2-(α-hydroxyphenylmethyl)morpholine-4-carboxylic acid t-butyl esterwith 1H-imidazole;carbon tetrabromide;triphenylphosphine in dichloromethane at 0 - 20; for 2 h;
Stage #2: 2-Ethoxyphenolwith potassium tert-butylate in tetrahydrofuran;tert-butyl alcohol;Reflux;
Stage #3: with trifluoroacetic acid in dichloromethane at 20; for 6 h;

References:

Liu, Cheng;Lin, Zhi-Wei;Zhou, Zhao-Hui;Chen, Hong-Bin [Organic and Biomolecular Chemistry,2017,vol. 15,# 25,p. 5395 - 5401]

Morpholine, 2-[(R)-(2-ethoxyphenoxy)phenylmethyl]-, hydrochloride (1:1), (2R)-

105017-40-1
0 suppliers
inquiry

105017-38-7
1 suppliers
inquiry

References

130115-07-0
1 suppliers
inquiry

105017-38-7
1 suppliers
inquiry

References

1,2-Propanediol, 3-amino-1-phenyl-, (1R,2R)-

1190855-50-5
0 suppliers
inquiry

105017-38-7
1 suppliers
inquiry

References

1190855-57-2 Synthesis

2-Morpholinemethanol, α-phenyl-, (αR,2R)-

1190855-57-2
2 suppliers
inquiry

105017-38-7
1 suppliers
inquiry

References