ChemicalBook CAS DataBase List rac N-Benzyl Nebivolol

rac N-Benzyl Nebivolol synthesis

7synthesis methods

Product Name:rac N-Benzyl Nebivolol
CAS Number:929706-85-4
Molecular formula:C29H31F2NO4
Molecular Weight:495.56

99199-90-3 Synthesis

6-Fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran

99199-90-3
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100-46-9 Synthesis

100-46-9
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929706-85-4
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Yield:929706-85-4 100%

Reaction Conditions:

in isopropyl alcohol;Reflux;

Steps:

13 Preparation of α,α'-[[(phenylmethyl)imino]bismethylene]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol] (Formula IV', where P=benzyl)

EXAMPLE 13 Preparation of α,α'-[[(phenylmethyl)imino]bismethylene]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol] (Formula IV', where P=benzyl) A round bottom flask is charged with [(R*S*)+(R*R*)]-6-fluoro-2-(oxiran-2-yl)chroman (25.3 g), isopropyl alcohol (350 mL), and benzylamine (6 g). The mixture is stirred under reflux conditions and reaction completion is verified using TLC. The solvent is distilled under vacuum below 50-55° C., to afford the title compound (35 g, ~100% yield).

References:

US2011/250454,2011,A1 Location in patent:Page/Page column 14

99199-60-7 Synthesis