RAGAGLITAZAR synthesis

Yield:222834-22-2 85%

Steps:

16 (+-) 3-[4-[2-(Phenoxazin-10-yl)ethoxy]phenyl]-2-ethoxypropanoic acid, sodium salt

EXAMPLE 16 (+-) 3-[4-[2-(Phenoxazin-10-yl)ethoxy]phenyl]-2-ethoxypropanoic acid, sodium salt The title compound (0.27 g, 85%) was prepared as a white solid from (+-) 3-[4-[2-(phenoxazin-10-yl)ethoxy]phenyl]-2-ethoxypropanoic acid (0.3 g, 0.72 mmol) obtained in example 15 by an analogous procedure to that described in example 12. mp: 194-202° C. ¹H NMR (CDCl₃, 200 MHz): δ0.92 (t, J=6.97 Hz, 3H), 2.65-2.82 (complex, 1H), 2.96-3.14 (complex, 2H), 3.31-3.41 (complex, 1H), 3.70-3.90 (complex, 3H), 3.94-4.04 (complex, 2H), 6.47-6.74 (complex, 10H), 7.05 (d, J=8.30 Hz, 2H).

References:

US6440961,2002,B1