Raltitrexed Impurity 1 synthesis
- Product Name:Raltitrexed Impurity 1
- CAS Number:1378372-01-0
- Molecular formula:C10H10N2O2
- Molecular Weight:190.2
112888-43-4
131 suppliers
$75.00/1g
1378372-01-0
19 suppliers
$153.00/100mg
Yield:1378372-01-0 49%
Reaction Conditions:
Stage #1: 4(3H)-oxo-6-(bromomethyl)-2-methyl quinazolinewith potassium carbonate;acetic acid in N,N-dimethyl-formamide at 20; for 1 h;
Stage #2: with potassium hydroxide in methanol;water;N,N-dimethyl-formamide; for 1 h;Reflux;
References:
Cao, Sheng-Li;Xu, Hong;Wang, Yao;Liao, Ji;Zhang, Jing-Jing;Li, Zhong-Feng;Guo, Yan-Wen;Li, Xiao-Rong;Cui, Xue-Mei;Xu, Xingzhi [Medicinal Chemistry,2012,vol. 8,# 2,p. 163 - 173] Location in patent:experimental part