RARECHEM AL BD 0561 synthesis

12synthesis methods

Product Name:RARECHEM AL BD 0561
CAS Number:40016-25-9
Molecular formula:C15H24O
Molecular Weight:220.35

49763-66-8
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40016-25-9
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$198.00/1g

Yield:40016-25-9 100%

Reaction Conditions:

Stage #1: 4-octylbenzaldehydewith methanol;sodium tetrahydroborate at 20; for 0.5 h;
Stage #2: with water;sodium hydroxide in diethyl ether;

Steps:

6.A

NaBH₄ (0.04 g; 1 .06 mmol) was added portion wise to a solution of the product of Example 3, Step A in MeOH (5 ml) at room temperature, with vigorous stirring. After 30 min of stirring, the mixture was evaporated to dryness, diluted to 10 ml with Et₂O and washed with 1 N NaOH, H₂O, brine, dried over anhydrous MgSO₄ and filtered. The filtrate was evaporated under reduced pressure to give the title compound (0.082 g; 100%), as colourless syrup, which was used in next step without further purification. ¹ H-NMR (CDCI₃) 7.26 (d, 2H, J = 8 Hz); 7.15 (d, 2H, J = 8 Hz); 4.64 (s, 2H); 2.58 (t, 2H, J = 7.9 Hz); 1 .56 (m, 3H); 1 .26 (m, 10H); 0.86 (t, 3H, J = 6.9 Hz).

References:

WO2010/43000,2010,A1 Location in patent:Page/Page column 51