rebamipide synthesis
- Product Name:rebamipide
- CAS Number:111911-90-1
- Molecular formula:C19H15ClN2O4
- Molecular Weight:370.79
4876-10-2
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Yield:-
Steps:
Multi-step reaction with 4 steps
2: 0.25 N HCl / Ambient temperature
3: 1.) 6 N HCl 2.) propylene oxide / 1.) reflux, 6 h 2.) EtOH, reflux, 15 min
4: 29 percent / K2CO3 / acetone; H2O / 2 h
References:
Otsubo;Morita;Uchida;Yamasaki;Kanbe;Shimizu [Chemical and Pharmaceutical Bulletin,1991,vol. 39,# 11,p. 2906 - 2909]
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111911-90-1
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