![](/CAS/GIF/302-79-4.gif)
Retinoic acid synthesis
- Product Name:Retinoic acid
- CAS Number:302-79-4
- Molecular formula:C20H28O2
- Molecular Weight:300.44
![all-trans-Retinol](/CAS/GIF/68-26-8.gif)
68-26-8
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$28.00/50mg
![Retinoic acid](/CAS/GIF/302-79-4.gif)
302-79-4
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$5.00/100mg
Yield:302-79-4 90.2%
Reaction Conditions:
with tris(triphenylphosphine)ruthenium(II) chloride;oxygen;bis-(3-methyl-1-imidazolyl)ethylene tetrafluoroborate in hexane at 50; under 760.051 Torr; for 3 h;Darkness;Reagent/catalyst;
Steps:
1.2
2) Take 1L of bis- (3-methyl-1-imidazole) ethylene tetrafluoroborate and add RuCl2 (PPh3) 3 (the added amount is 1mol% of tretinoin), stir to dissolve,Then add 2mol of retinoid acid in the dark,The reaction was carried out in an oxygen atmosphere of 1 atm at 50 ° C for 3 hours. After the reaction, n-hexane was added for extraction,The extract was collected and dried to obtain crude tretinoin.The crude retinoic acid product obtained above was suspended in absolute ethanol, heated to 80 ° C under reflux to dissolve, and then slowly cooled to 10 ° C with stirring, allowed to stand, filtered, washed with a small amount of ethanol, and dried in vacuo to obtain pure retinoic acid product. The total yield is 90.2% and the purity is 99%.The structure identification of the prepared tretinoin was carried out, and the obtained compound was indeed the target compound.
References:
CN111087335,2020,A Location in patent:Paragraph 0020; 0029; 0031-0032; 0043; 0047; 0051
![ethyl retinoate](/CAS/GIF/3899-20-5.gif)
3899-20-5
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![Retinoic acid](/CAS/GIF/302-79-4.gif)
302-79-4
735 suppliers
$5.00/100mg
![Retinal](/CAS/GIF/116-31-4.gif)
116-31-4
236 suppliers
$18.00/250mg
![Retinoic acid](/CAS/GIF/302-79-4.gif)
302-79-4
735 suppliers
$5.00/100mg
![Retinal](/CAS/GIF/116-31-4.gif)
116-31-4
236 suppliers
$18.00/250mg
![2,4,6,8-Nonatetraenal, 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-, oxime, (1Z,2E,4E,6E,8E)-](/CAS/20210305/GIF/67890-45-3.gif)
67890-45-3
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![Retinoic acid](/CAS/GIF/302-79-4.gif)
302-79-4
735 suppliers
$5.00/100mg
![2,4,6,8-Nonatetraenal, 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-, oxime, (1E,2E,4E,6E,8E)-](/CAS/20210305/GIF/67890-46-4.gif)
67890-46-4
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