ribavirin 2',3',5'-triacetate synthesis
- Product Name:ribavirin 2',3',5'-triacetate
- CAS Number:40372-03-0
- Molecular formula:C14H18N4O8
- Molecular Weight:370.32
108-24-7
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Yield:40372-03-0 100%
Reaction Conditions:
with pyridine at 20; for 22 h;Concentration;
Steps:
1D Synthesis of 2’ 3’ 5’-O-triacetyl-(3-D-ribothranosyl)-1 ,2,4-triazole-3-carboxamide 8
Synthesis of 2’ 3’ 5’-O-triacetyl-(3-D-ribothranosyl)-1 ,2,4-triazole-3-carboxamide 8 A suspension of ribavirin 1 (568 mg, 2.33 mmol) in aceticanhydride (4 mE) and pyridine (1 mE) was stirred at roomtemperature for 22 hours. The mixture was concentratedunder reduced pressure and the residue was dried under highvacuum to afford the product in quantitative yield.
References:
US9149538,2015,B2 Location in patent:Page/Page column 35; 36; 37