RO-2468 synthesis
- Product Name:RO-2468
- CAS Number:1360821-21-1
- Molecular formula:C30H30Cl2FN5O4
- Molecular Weight:614.49
1000342-80-2
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$130.00/50mg
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Yield:-
Steps:
Multi-step reaction with 6 steps
1.1: piperidine / methanol / 0.17 h
1.2: 3 h / 50 °C
2.1: lithium hydroxide / tetrahydrofuran / 0.17 h / 40 °C
2.2: 18 h / 40 °C
3.1: Resolution of racemate
4.1: lithium hydroxide; water / tetrahydrofuran / 20 °C
5.1: ammonium hydroxide / tetrahydrofuran / 17 h / 20 °C
6.1: ammonium hydroxide / tetrahydrofuran / 0.33 h / 20 °C
References:
Zhang, Zhuming;Chu, Xin-Jie;Liu, Jin-Jun;Ding, Qingjie;Zhang, Jing;Bartkovitz, David;Jiang, Nan;Karnachi, Prabha;So, Sung-Sau;Tovar, Christian;Filipovic, Zoran M.;Higgins, Brian;Glenn, Kelli;Packman, Kathryn;Vassilev, Lyubomir;Graves, Bradford [ACS Medicinal Chemistry Letters,2014,vol. 5,# 2,p. 124 - 127]
85070-48-0
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$10.00/5g
1360821-21-1
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