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ChemicalBook CAS DataBase List Ronacaleret

Ronacaleret synthesis

2synthesis methods
2-Propanol, 1-(5-bromo-2,3-difluorophenoxy)-3-[[2-(2,3-dihydro-1H-inden-2-yl)-1,1-dimethylethyl]amino]-, (2R)-

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Ronacaleret

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Yield:-

Steps:

Multi-step reaction with 4 steps
1: palladium diacetate; tris-(o-tolyl)phosphine; N-ethyl-N,N-diisopropylamine / 3.5 h / 115 °C / Inert atmosphere
2: sodium hydroxide / ethanol; water / 12 h / 20 °C
3: hydrogenchloride / diethyl ether; acetonitrile
4: 5 % Pd/CaCO3; hydrogen / acetic acid; ethyl acetate / 15 h

References:

US9227914,2016,B2