![](/CAS/GIF/225920-05-8.gif)
(S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol synthesis
- Product Name:(S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol
- CAS Number:225920-05-8
- Molecular formula:C10H8F6O
- Molecular Weight:258.16
![3',5'-Bis(trifluoromethyl)acetophenone](/CAS/GIF/30071-93-3.gif)
30071-93-3
363 suppliers
$10.00/10 g
![(S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol](/CAS/GIF/225920-05-8.gif)
225920-05-8
211 suppliers
$5.00/250mg
Yield:225920-05-8 100%
Reaction Conditions:
with potassium formate;Ru(OTf)[(S,S)-iso-BuSO2dpen](p-cymene) in methanol at 50; for 24 h;Inert atmosphere;
Steps:
23
Working Example 23; A ruthenium complex Ru(OTf)[(S,S)-iso-BuSO2dpen] (p-cymene) (1.4 mg, 0.002 mmol), potassium formate (1.0 g, 12 mmol), and 3',5'-bis(trifluoromethyl)acetophenone (2.56 g, 10 mmol, substrate/catalyst ratio=5000) were set in a 20 mL glass Schlenk-type reaction tube under an argon atmosphere. Methanol (6 mL) was added thereto and stirred at 50° C. for 24 hours to give (S)-1-[3',5'-bis(trifluoromethyl)phenyl]ethanol at 100% yield and 87.7% ee optical purity.
References:
Kanto Kagaku Kabushiki Kaisha US2011/282077, 2011, A1 Location in patent:Page/Page column 8
![3,5-Bis(trifluoromethyl)benzaldehyde](/CAS/GIF/401-95-6.gif)
401-95-6
291 suppliers
$8.00/5g
![METHYLTITANIUM TRIISOPROPOXIDE](/CAS/GIF/18006-13-8.gif)
18006-13-8
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![(S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol](/CAS/GIF/225920-05-8.gif)
225920-05-8
211 suppliers
$5.00/250mg