(S)-1-(p-Tolyl)ethanaMine hydrochloride synthesis

Yield:84499-72-9 94%

Reaction Conditions:

with chloro(1,5-cyclooctadiene)rhodium(I) dimer;zhaophos;hydrogen in isopropyl alcohol at 25; under 7600.51 Torr; for 24 h;Inert atmosphere;Glovebox;Autoclave;enantioselective reaction;

References:

Zhao, Qingyang;Wen, Jialin;Tan, Renchang;Huang, Kexuan;Metola, Pedro;Wang, Rui;Anslyn, Eric V.;Zhang, Xumu [Angewandte Chemie - International Edition,2014,vol. 53,# 32,p. 8467 - 8470][Angew. Chem.,2014,vol. 126,# 32,p. 8607 - 8610,4] Location in patent:supporting information