ChemicalBook CAS DataBase List (S)-(-)-1-(P-TOLYL)ETHYLAMINE

(S)-(-)-1-(P-TOLYL)ETHYLAMINE synthesis

9synthesis methods

Product Name:(S)-(-)-1-(P-TOLYL)ETHYLAMINE
CAS Number:27298-98-2
Molecular formula:C9H13N
Molecular Weight:135.21

17640-21-0
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42070-98-4
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Acetamide, 2-methoxy-N-[(1R)-1-(4-methylphenyl)ethyl]-

296236-17-4
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27298-98-2
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$8.00/250mg

Yield:27298-98-2 45% ，296236-17-4 45%

Reaction Conditions:

with Novozym 435 at 23; for 3 h;Molecular sieve;Enzymatic reaction;optical yield given as %ee;enantioselective reaction;

Steps:

4.3. Preparative-scale solvent-free kinetic resolution of rac-1a-i

General procedure: One of the amines rac-1a-i (2 mmol) and isopropyl methoxyacetate (2 mmol) were added into a reaction vessel containing Novozym 435 (25 mg) and molecular sieves (4 ?, 50 mg). The reaction mixture was shaken (170 rpm) at room temperature (23 °C) if not otherwise stated. The reaction was stopped by filtering off the enzyme at (50 +/- 0.5)% conversion. Isolation of the products was performed by silica gel chromatography using a mixture of hexane and ethylacetate and/or mixture of dichloromethane and methanol as eluent.

References:

Paeivioe, Mari;Perkioe, Paeivi;Kanerva, Liisa T. [Tetrahedron Asymmetry,2012,vol. 23,# 3-4,p. 230 - 236] Location in patent:experimental part

122-00-9 Synthesis