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(S)-2-((3-CHLOROPHENOXY)METHYL)OXIRANE synthesis

2synthesis methods
-

Yield:129098-53-9 68%

Reaction Conditions:

Stage #1: 3-monochlorophenolwith sodium hydride in N,N-dimethyl-formamide;mineral oil at 20; for 0.5 h;Inert atmosphere;
Stage #2: (S)-Glycidyl tosylate in N,N-dimethyl-formamide at 20; for 15 h;Inert atmosphere;

References:

Kuriyama, Masami;Hamaguchi, Norihisa;Yano, Gemba;Tsukuda, Kotaro;Sato, Kanako;Onomura, Osamu [Journal of Organic Chemistry,2016,vol. 81,# 19,p. 8934 - 8946]

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