(S)-2-AZETIDINEMETHANOL synthesis
- Product Name:(S)-2-AZETIDINEMETHANOL
- CAS Number:104587-62-4
- Molecular formula:C4H9NO
- Molecular Weight:87.12
69684-69-1
72 suppliers
$60.00/100mg
104587-62-4
56 suppliers
$145.00/100MG
Yield:-
Reaction Conditions:
in tetrahydrofuran;water
Steps:
60.a EXAMPLE 60
(a) 13.5 g of lithium aluminum hydride were suspended at about 0° in 550 ml of absolute tetrahydrofuran under argon and thereupon there was added portionwise within about a half hour methyl (S)-azetidine-2-carboxylate hydrochloride. The mixture was stirred at about 5° for 30 minutes, then at about 20° for 3 hours. Thereafter, the mixture was again cooled and 60 ml of water were added dropwise. After stirring at room temperature for 3 days, the white precipitate was removed by filtration and extracted exhaustively with chloroform. The filtrate was evaporated and distilled in vacuo together with the extract obtained above. There was obtained (S)-2-azetidinemethanol as a colorless oil of b.p. 44°-46°/0.06 Torr.
References:
Hoffmann-La Roche Inc. US4735940, 1988, A
2133-34-8
301 suppliers
$19.00/50mg
104587-62-4
56 suppliers
$145.00/100MG