S-[2-(dimethylamino)ethyl] ethanethioate synthesis
- Product Name:S-[2-(dimethylamino)ethyl] ethanethioate
- CAS Number:18719-14-7
- Molecular formula:C6H13NOS
- Molecular Weight:147.24
Yield:18719-14-7 130 g
Reaction Conditions:
with potassium carbonate in water at 5 - 25; for 6 h;Reagent/catalyst;
Steps:
1-5
In a 5 L three-necked flask, 121.6 g of potassium carbonate was weighed into a bottle, and 1.5 L of water was added.The mixture was dissolved and stirred, and 150.8 g of dimethylaminobromoethane hydrochloride was added thereto.All of it was freed to obtain a clear liquid. The ice salt bath is cooled to 5-10 ° C.Further, 136.8 g of potassium thioacetate was added to the bottle, and after the addition was completed, the mixture was stirred at room temperature (25 ° C) for 6 hours, during which the solid properties of the system and the color of the system were white to brown.After the reaction was completed, 2 L of ethyl acetate was added to the system, and the mixture was separated.The obtained organic phase was dried over anhydrous magnesium sulfate and filtered.The filtrate was concentrated to give the intermediate dimethylaminoethyl thioacetic acid 130 g.
References:
CN109879787,2019,A Location in patent:Paragraph 0065-0067; 0074-0076; 0083-0085; 0092-0094; 0101
