(S)-3-(3-METHOXYPHENYL)PIPERIDINE synthesis

14synthesis methods

Product Name:(S)-3-(3-METHOXYPHENYL)PIPERIDINE
CAS Number:88784-37-6
Molecular formula:C12H17NO
Molecular Weight:191.27

Piperidine, 3-(3-methoxyphenyl)-1-(phenylmethyl)-, (3S)-

89874-44-2
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88784-37-6
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Yield:88784-37-6 94%

Reaction Conditions:

with hydrogen;ammonium formate;palladium on activated charcoal in methanol; for 1 h;Heating / reflux;

Steps:

S-3- (3-Methoxy-phenyl) -piperidine (S-9) l-Benzyl-3- (3- methoxy-phenyl) -piperidine (S-8) (306 mg, 1.09 mmol) was added to Pd/C (250 mg) , ammoniumformate (270 mg, 62.06 mmol) and 125 mL of methanol. The reaction mixture was brought to reflux while stirring in a nitrogen atmosphere for 1 h. Then the reaction mixture was left to cool to room temperature. The reaction mixture was filtered. To the filtrate some methanol was added and refluxed shortly. Again, this was filtered. Both methanol fractions were combined and the solvent was evaporated. Yield: 196 mg (94%). GCMS (EI): m/z 191 (M+), 162 (M-29); GC (100-320⁰C, 15°C/min): 4.3 min.

References:

WO2008/127188,2008,A1 Location in patent:Page/Page column 25

79601-21-1 Synthesis