(S)-3-(4-Fluoro-2-methylphenyl)piperazin-2-one synthesis

2synthesis methods

Product Name:(S)-3-(4-Fluoro-2-methylphenyl)piperazin-2-one
CAS Number:334477-18-8
Molecular formula:C11H13FN2O
Molecular Weight:208.23

3-(4-fluoro-2-methylphenyl)-5,6-dihydropyrazin-2(1H)-one(WXG03146)

334477-08-6
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(S)-3-(4-Fluoro-2-methylphenyl)piperazin-2-one

334477-18-8
11 suppliers
$945.00/100mg

(R)-3-(4-Fluoro-2-methylphenyl)piperazin-2-one

1153574-57-2
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$1012.00/1g

Yield:56 % ee

Reaction Conditions:

with C₃₇H₄₂IrNOPRu⁽¹⁺⁾*C₃₂H₁₂BF₂₄^(1-);hydrogen in dichloromethane at 20; under 52505.3 Torr; for 72 h;Autoclave;Overall yield = 72 %; enantioselective reaction;

References:

Wang, Yanzhao;Liu, Yuanyuan;Li, Kun;Yang, Guoqiang;Zhang, Wanbin [Advanced Synthesis and Catalysis,2017,vol. 359,# 11,p. 1933 - 1941] Location in patent:supporting information

334477-07-5 Synthesis

334477-07-5
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334477-18-8
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$945.00/100mg

1153574-57-2
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$1012.00/1g

References