(S)-4,4-difluoropiperidin-3-ol hydrochloride synthesis

Yield:-

Reaction Conditions:

with hydrogenchloride in 1,4-dioxane at 20; for 1 h;

Steps:

2 EXAMPLE 2 (3S)-4,4-Difluoropiperidin-3-ol hydrochloride

4M HC1 in dioxane (19.6 mL, 78 mmol) was added to tert-butyl (3S)-4,4-difluoro- 3-(quinolin-2-yloxy)piperidine-l-carboxylate (6.19 g, 26.1 mmol) and the suspension was stirred at ambient temperature for 1 h. The resulting white solid was filtered, washed with dioxane (2 x 20 mL), and dried provide the title compound as a white solid.

References:

WO2014/113303,2014,A1 Location in patent:Page/Page column 44-45