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(S)-4-BROMO-3-HYDROXY-BUTYRIC ACID METHYL ESTER synthesis

2synthesis methods
17790-81-7 Synthesis
methyl 4-bromo-3-oxo-butanoate

17790-81-7
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Yield:88759-56-2 86%

Reaction Conditions:

with D-glucose in acetic acid butyl ester at 30; for 4 h;aq. phosphate buffer;Enzymatic reaction;optical yield given as %ee;

References:

Asako, Hiroyuki;Shimizu, Masatoshi;Makino, Yoshihide;Itoh, Nobuya [Tetrahedron Letters,2010,vol. 51,# 19,p. 2664 - 2666] Location in patent:experimental part