S(-)-BACLOFEN HCL synthesis

5synthesis methods

Product Name:S(-)-BACLOFEN HCL
CAS Number:63701-56-4
Molecular formula:C10H13Cl2NO2
Molecular Weight:250.1217

2-Butenoic acid, 4-azido-3-(4-chlorophenyl)-, ethyl ester

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63701-55-3 Synthesis

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Yield:-

Reaction Conditions:

Stage #1: ethyl 4-azido-3-(4-chlorophenyl)-2-butenoatewith hydrogen;Ru(II)-(S)-(-)-BINAP in methanol at 50; under 10343 Torr; for 20 h;
Stage #2: with sodium tetrahydroborate;cobalt(II) chloride in methanol; for 0.5 h;
Stage #3: with hydrogenchloride at 100; for 10 h;Title compound not separated from byproducts;

References:

Thakur, Vinay V.;Nikalje, Milind D.;Sudalai [Tetrahedron Asymmetry,2003,vol. 14,# 5,p. 581 - 586]

104-88-1 Synthesis