S-BENZYL-N-BOC-ETHANETHIOLAMINE synthesis
- Product Name:S-BENZYL-N-BOC-ETHANETHIOLAMINE
- CAS Number:873330-01-9
- Molecular formula:C14H21NO2S
- Molecular Weight:267.39
100-53-8
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$10.00/1g
![TERT-BUTYL N-[2-(TOSYLOXY)ETHYL]CARBAMATE](/CAS/GIF/158690-56-3.gif)
158690-56-3
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$26.00/1g
873330-01-9
16 suppliers
$85.00/50mg
Yield:873330-01-9 83%
Reaction Conditions:
with caesium carbonate in N,N-dimethyl-formamide; for 18 h;
Steps:
67.C
67C: N-Boc-2-Benzylsulfanyl-ethylamine; N-Boc-2-Tosyl-ethylamine (100 mg, 0.32 mmol) was added to a mixture of benzylmercaptan (45 mL, 0.38 mmol) and CsaCOs (68 mg, 0.21 mmol) in 1.6 mL of dry DMF. The reaction was stirred for 18 hours after which time the reaction mixture was poured onto water. The aqueous layer was extracted three times with AcOEt. The combined organic layers were washed with water, saturated NaHCOs and brine, dried over Na2SC>4 and concentrated. The residue was purified using SiC>2 with AcOEt/Petroleum ether 5:95 to 15:75. A yellow oil was obtained (72 mg, 83%). NMR 'H (ppm, CDC13): 7.31-7.25 (m, 5H), 4.79 (br. s., 1H), 3.70 (s, 2H), 3.25 (m, 2H), 2.55-2.53 (m, 2H), 1.43 (s, 9H).
References:
WO2006/2474,2006,A1 Location in patent:Page/Page column 174
7150-72-3
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106-53-6
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$12.00/1g
873330-01-9
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$85.00/50mg
24424-99-5
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$13.50/25G
873330-01-9
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$85.00/50mg
26690-80-2
327 suppliers
$6.00/5g
873330-01-9
16 suppliers
$85.00/50mg