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S-(+)-FLUOXETINE HYDROCHLORIDE synthesis

10synthesis methods
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Yield:114247-06-2 90%

Reaction Conditions:

Stage #1: (S)-N-methyl-3-amino-1-phenyl-1-propanolwith sodium hydride in dimethyl sulfoxide at 70; for 0.5 h;
Stage #2: 4-chlorobenzotrifluoride in dimethyl sulfoxide at 90; for 2 h;

References:

Li, Yangzhou;Li, Zhiming;Li, Feng;Wang, Quanrui;Tao, Fanggang [Organic and Biomolecular Chemistry,2005,vol. 3,# 14,p. 2513 - 2518]

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