(S)-(+)-Ketamine hydrochloride synthesis

Yield:-

Reaction Conditions:

Resolution of racemate;

Steps:

(R)-ketamine hydrochloride was separatedfrom (R,S)-ketamine hydrochloride through a modification of the publishedprocedure for the resolution of (S)-ketamine (Steiner et al., 2000).

References:

Li, Yibai;Coller, Janet K.;Hutchinson, Mark R.;Klein, Kathrin;Zanger, Ulrich M.;Stanley, Nathan J.;Abell, Andrew D.;Somogyi, Andrew A. [Drug Metabolism and Disposition,2013,vol. 41,# 6,p. 1264 - 1272]

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