SALOR-INT L172227-1EA synthesis
- Product Name:SALOR-INT L172227-1EA
- CAS Number:169945-47-5
- Molecular formula:C15H14N2O5
- Molecular Weight:302.28
Yield:169945-47-5 48.7 g
Reaction Conditions:
with triethylamine in chloroform at 90; for 18 h;Inert atmosphere;
Steps:
1-1.1
(1) A compound 1, 2,5-dimethoxyaniline (25 g, 0.163 mol), 36.34 g (0.195 mol) of 4-nitrobenzyl chloride, and 45.5 ml (0.326 mol) of triethylamine were dissolved in chloroform (700 ml) in a reaction vessel equipped with a stirrer, a thermometer, a cooling tube, and a temperature controller, followed by heating and reaction at 90° C. for 18 hr in a nitrogen atmosphere. After cooling to room temperature, the resulting reaction solution was diluted with water and dichloromethane, and the phases thereof were separated from each other. Thereafter, the organic layer was extracted and then dried over magnesium sulfate. The resulting solid was washed with hexane, thus obtaining a compound 2 (48.7 g). GC-MS (EI): m/z 302[M+H+]
References:
US2021/171478,2021,A1 Location in patent:Paragraph 0084-0085
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