ChemicalBook CAS DataBase List SAR245409

SAR245409 synthesis

12synthesis methods

Product Name:SAR245409
CAS Number:934493-76-2
Molecular formula:C13H14N6O
Molecular Weight:270.29

4-Chloro-6-methyl-2-(methylthio)pyrimidine

17119-73-2
139 suppliers
$9.00/250mg

934493-76-2
68 suppliers
$84.00/5mg

Yield:-

Steps:

Multi-step reaction with 7 steps
1.1: water / 3 h / 50 °C / Heating / reflux
2.1: Iodine monochloride / methanol / 0 °C
3.1: (R)-(+)-2,2′-bis(diphenylphosphino)-1,1′-binaphthalene; triethylamine / palladium diacetate / DMA / 100 °C
4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine / 15 h / 20 °C / Heating / reflux
5.1: bromine / dichloromethane / 20 °C
6.1: triethylamine / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 4 h / 20 °C / Heating / reflux
7.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 20 °C
7.2: 20 °C

References:

EXELIXIS, INC. WO2008/124161, 2008, A1