Serine, 3-methoxy-O-methyl-, methyl ester (9CI) synthesis

Yield:120105-69-3 96%

Reaction Conditions:

with hydrogen in methanol at 20; for 3 h;

Steps:

5 A preparation process of 2-amino-3,3-dimethoxypropionic acid methyl ester (compound 12 in formula III, hereinafter referred to as compound 12), is specifically as follows:

Compound 11 (38.6g, 0.2mol) was dissolved in 580mL methanol,Add Raney nickel (10g, wet weight), and stir with hydrogen gas (hydrogen bag) at room temperature.After reacting for 3 hours, the reaction is over.The nickel was filtered off with suction, and the mother liquor was concentrated and dried under reduced pressure to obtain compound 12 (31.3 g, 96%) as a brown oil.

References:

CN113072495,2021,A Location in patent:Paragraph 0052-0056