ChemicalBook CAS DataBase List Serricornin

Serricornin synthesis

6synthesis methods

Product Name:Serricornin
CAS Number:72598-35-7
Molecular formula:C11H22O2
Molecular Weight:186.29

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72598-35-7
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Yield:-

Steps:

Multi-step reaction with 6 steps
1: 1) titanium tetraisopropoxide, L-(+)-diethyltartrate, molecular sieves 4A, t-butyl hydroperoxide, 2) Me₂S, aq. NaF / 1) CH₂Cl₂, ClCH₂CH₂Cl, -23 deg C, 2 h, 2) r.t., 24 h
2: 1) (COCl)2/DMSO, 2) Et₃N / 1) 1) CH₂Cl₂, -78 deg C, 30 min, 2) r.t., 1 h
3: tetrahydrofuran / 2 h / 0 °C
4: formic acid, Et₃N / Pd₂(dba)3CHCl₃-P(OMe)3 / dioxane / 2 h / Ambient temperature; var. phosphorus ligands; var. times; var. concentrations of formic acid
5: 83 percent / H₂ / 5percent Pd/C / methanol / 24 h / Ambient temperature
6: p-TsOH / tetrahydrofuran; H₂O / 5 h / 50 °C