Sevelamer synthesis

Yield:13348-89-5 41.8%

Reaction Conditions:

at 30; for 5 h;

Steps:

5

Synthesis Example 5Allylamine (112.4 mL, 85.54 g, 1.5 mol) was placed in a 4-necked flask and a reflex condenser, thermometer, dropping funnel, and mechanical stirrer were attached. Glycidol (2,3- epoxy- 1 -propanol, 37.8 g, 0.5 mol) was added to the dropping funnel, and added by drops over approximately 10 minutes while mixing at 30°C. A GC measurement was performed each hour starting at the time that dropwise addition was completed in order to confirm the progress of the reaction. 5 hours after dropwise addition was completed it was confirmed that the glycidol peak was 1% or less and the reaction was terminated. The solution was concentrated in an evaporator, and then purified by reduced pressure installation (full vac, bp 52°C). The yield was 27.43 g (41.8% yield), and the GC purity was 98.7%.

References:

WO2011/116206,2011,A1 Location in patent:Page/Page column 40