SINOVA SL-03967 synthesis
- Product Name:SINOVA SL-03967
- CAS Number:107259-05-2
- Molecular formula:C11H19NO4
- Molecular Weight:229.27
24424-99-5
822 suppliers
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42303-42-4
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$6.00/1g
107259-05-2
61 suppliers
$60.00/100mg
Yield: 97%
Reaction Conditions:
with triethylamine in dichloromethane at 23;
Steps:
1.3.3.1 Step 1: Eth vi 1 -((tert-butoxycarbonyl )am ino)cyclopropanecarboxylate
To a solution of ethyl 1-aminocyclopropanecarboxylate hydrochloride (3.22 g, 19.4 mmol) in DCM (35 mL) was added triethylamine (2.71 mL, 19.4 mmol) upon which a suspension was obtained. A solution of Boc2O (4.24 g, 19.4 mmol) in DCM (5 mL) was added dropwise over ca. 2 mm. The reaction mixturewas stirred at RT overnight. Aqueous I M KHSO4 (100 mL) and DCM (50 mL) were added. The organic layer was separated, dried (Na2SO4), evaporated under reduced pressure and co-evaporated with THF (2x), to afford 4.31 g (97%) of the desired product.
References:
GRÜNENTHAL GMBH;REICH, Melanie;SCHUNK, Stefan;JAKOB, Florian;DAMANN, Nils;HAURAND, Michael;HAMLYN, Richard;ROGERS, Marc;SUTTON, Kathy;SKONE, Philip WO2015/90603, 2015, A1 Location in patent:Page/Page column 59; 60
3697-66-3
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75-65-0
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$10.00/10ml
107259-05-2
61 suppliers
$60.00/100mg
24424-99-5
822 suppliers
$13.50/25G
72784-47-5
51 suppliers
$45.00/10mg
107259-05-2
61 suppliers
$60.00/100mg
1559-02-0
320 suppliers
$5.00/5g
107259-05-2
61 suppliers
$60.00/100mg