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Siponimod synthesis
- Product Name:Siponimod
- CAS Number:916806-97-8
- Molecular formula:C14H15F3O2
- Molecular Weight:272.26
![4-(cyclohex-1-en-1-yl)-3-(trifluoromethyl)benzoic acid](/CAS/20180629/GIF/1034188-31-2.gif)
1034188-31-2
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Yield: 88%
Reaction Conditions:
with palladium on activated charcoal;hydrogen in methanol at 50; under 7600.51 Torr; for 72 h;
Steps:
1.6 Step 6 (0264) (0265) [00250] 4-cyclohexyl-3-(trifluoromethyl)benzoic acid
Step 6 (0264) (0265) [00250] 4-cyclohexyl-3-(trifluoromethyl)benzoic acid: To a solution of 4-(cyclohex-1-en- 1-yl)-3-(trifluoromethyl)benzoic acid (6.4 g, 23.68 mmol, 1.00 equiv.) in methanol (60 mL), Pd/C (0.64 g) was added. The resulting solution was stirred for 72 h at 50 oC with an inert atmosphere of H2 (10 atm.). The reaction mixture was cooled. The solids were filtered out. The resulting mixture was concentrated under vacuum to afford 5.7 g (88%) of 4-cyclohexyl- 3-(trifluoromethyl) benzoic acid as a white solid. LC-MS: m/z = 271 [M-H]-.
References:
AUSPEX PHARMACEUTICALS, INC.;ZHANG, Chengzhi;CHAKMA, Justin WO2017/120124, 2017, A1 Location in patent:Paragraph 00249-00250
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1000210-73-0
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124-38-9
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![4-BROMO-3-(TRIFLUOROMETHYL)BENZOIC ACID](/CAS/GIF/161622-14-6.gif)
161622-14-6
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$10.00/1g
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![Cyclohexanone](/CAS/GIF/108-94-1.gif)
108-94-1
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$12.00/50g
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