ChemicalBook CAS DataBase List Solifenacin Impurity 2

Solifenacin Impurity 2 synthesis

1synthesis methods

Product Name:Solifenacin Impurity 2
CAS Number:1229227-22-8
Molecular formula:C22H18N2O4
Molecular Weight:374.39

1-phenyl-1,2-dihydroisoquinolin-3(4H)-one

17507-05-0
42 suppliers
$45.00/250mg

1229227-22-8
17 suppliers
inquiry

Yield:-

Steps:

Multi-step reaction with 3 steps
1: sodium tetrahydroborate; iodine / tetrahydrofuran / 16 h / Inert atmosphere; Reflux
2: hydrogenchloride; borane-ammonia complex / aq. phosphate buffer / 37 °C / pH 7.8
3: triethylamine / tetrahydrofuran / 2 h / 0 - 25 °C / Inert atmosphere

References:

Ghislieri, Diego;Green, Anthony P.;Pontini, Marta;Willies, Simon C.;Rowles, Ian;Frank, Annika;Grogan, Gideon;Turner, Nicholas J. [Journal of the American Chemical Society,2013,vol. 135,# 29,p. 10863 - 10869]

Solifenacin Impurity 2 Related Search:

Solifenacin Related Compound 25 3-Quinuclidinone hydrochloride 1-Phenyl-1,2,3,4-tetrahydro-isoquinoline 1-Phenyl-3,4-dihydroisoquinoline Solifenacin N-Oxide Solifenacin Impurity 1 HCl (R)-(-)-3-Quinuclidinol 1-Azabicyclo[2.2.2]octan-3-ol, 3-acetate, (3R)- Dimethyl carbonate 3-Quinuclidinol