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ChemicalBook CAS DataBase List Sudexanox

Sudexanox synthesis

7synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 6 steps
1: Cu
2: polyphosphoric acid / tetrahydrothiophene 1,1-dioxide
3: H2SO4 / Heating
4: SO2Cl2, SiO2 / CH2Cl2
5: NaN3, polyphosphoric acid
6: aq. NaOH / ethanol

References:

Barnes,A.C. et al. [Journal of Medicinal Chemistry,1979,vol. 22,p. 418 - 424]

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