TAK-733 synthesis
- Product Name:TAK-733
- CAS Number:1035555-63-5
- Molecular formula:C17H15F2IN4O4
- Molecular Weight:504.23
1035555-51-1
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1035555-63-5
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Yield: 33%
Reaction Conditions:
with Selectfluor in N,N-dimethyl-formamide;acetonitrile at 20; for 0.166667 h;
Steps:
18
Example 18: (i?)-3-(2,3-Dihydroxypropyl)-6-fluoro-5-(2-fluoro-4-iodophenylamino)-8- methylpyrido[2,3-d]pyrimidine-4,7(3/f,8H)-dione; To a solution of (i?)-3-(2,3-dihydroxypropyl)-5-(2-fluoro-4-iodophenylamino)- 8-methylpyrido[2,3-d]pyrimidine-4,7(3/f,8H)-dione (example 6) (1 g, 2.06 mmol, 1 eq) in DMF (19 mL) was added dropwise a mixture of Selectfluor (801 mg, 2.26 mmol, 1.1 eq)
References:
TAKEDA PHARMACEUTICAL COMPANY LIMITED WO2008/79814, 2008, A2 Location in patent:Page/Page column 122-123
1000210-73-0
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1035555-63-5
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1122-67-4
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1035555-63-5
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1035556-23-0
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1035555-63-5
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1035556-25-2
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1035555-63-5
91 suppliers
$26.00/500μg