Taurolidine synthesis
- Product Name:Taurolidine
- CAS Number:19388-87-5
- Molecular formula:C7H16N4O4S2
- Molecular Weight:284.36
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Yield:19388-87-5 70%
Reaction Conditions:
with sodium hydrogencarbonate in water; pH=7 - 8; for 4 h;
Steps:
4 Taurolidine (Formula I)
To a solution of 100 g Taurinamide succinate in water is added sat sodium bicarbonate solution and pH adjusted to 7-8.
To the solution was added formaldehyde (50 ml) and allowed to stir for 4 h.
The solid obtained was filtered and washed with water to give Taurolidine.
The title compound was obtained in about 70% yield and about 98% purity.
References:
US2013/237700,2013,A1 Location in patent:Paragraph 0028