tert-butyl(2-methylpropyl)amine synthesis

7synthesis methods

Product Name:tert-butyl(2-methylpropyl)amine
CAS Number:56951-66-7
Molecular formula:C8H19N
Molecular Weight:129.24

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Yield: 48%

Reaction Conditions:

with nickel;hydrogen in neat (no solvent) at 160; under 760.051 Torr;Flow reactor;

Steps:

Reductive amination (general procedure)
General procedure: The reaction was performed in a continuous reactor at atmospheric pressure and temperature 60 - 240°. Depending on the boiling point of the substrates, the reaction could occur either in gas phase or in the gas-liquid-solid catalyst system. The laboratory-scale reactor was manufactured of a 121810 steel tube with inner diameter 9 mm and the heating zone height 50 mm (electric oven heating). The catalyst layer was positioned in the middle part of the reactor, sandwiched between the pieces of inert filler (quartz attachment). Liquid aldehyde (or ketone) and amine were fed at certain ratio, and the desired hydrogen feeding rate was set. Feeding rate of the liquid mixture 0.9 - 1.8 L/(kg_kat h). Hydrogen supply rate 250 - 1500 L/(kg_cat h) (5 - 15-fold molar excess).

References:

Mokhov, V. M.;Nebykov, D. N.;Paputina, A. N.;Popov, Yu. V.;Shishkin, E. V. [Russian Journal of General Chemistry,2019,vol. 89,# 12,p. 2333 - 2340][Zh. Obshch. Khim.,2019,vol. 89,# 12,p. 1807 - 1815,9]