tert-butyl 3,6-diiodo-9H-carbazole-9-carboxylate synthesis
- Product Name:tert-butyl 3,6-diiodo-9H-carbazole-9-carboxylate
- CAS Number:1122624-08-1
- Molecular formula:C17H15I2NO2
- Molecular Weight:519.12
57103-02-3
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Yield:1122624-08-1 90%
Reaction Conditions:
with dmap at 20; for 4 h;
Steps:
14
To this solution, di-/er/-butyl dicarbonate (6.2 g, 14.4 mmol) was first added, and then 4-dimethylaminopyridine (2 g, 14.4 mmol) was carefully added in small increments (gas evolved). After stirring for 4 hours at room temperature, the precipitate was filtered, the reaction mixture was concentrated to half volume, and the precipitate was filtered again. The same procedure was repeated once more and the precipitates were combined and washed with methanol to give 4 g of DF-I- 25.Yield:90%. NMR (300 MHz, CDC13, δ): δ 8.13 (2.0H, d, J = 1.5 Hz), 7.99 (2.0H, d, J = 8. = 8.8, 1.5 Hz), 1.74 (9.0H, s).
References:
WO2012/88316,2012,A1 Location in patent:Page/Page column 45-49
86-74-8
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