tert-butyl 3-aminopropyl(isopropyl)carbamate synthesis

Yield:1111236-12-4 94.3%

Reaction Conditions:

with hydrogen;palladium 10% on activated carbon in methanol at 20;

Steps:

A.A17.c

c) Preparation of intermediate 51; Pd/C 10 % (2.5 g) was suspended in MeOH (125 ml). Intermediate 50 (27.8 g, 0.0700 mol) in MeOH (125 ml) was added (under N₂ flow). The reaction mixture was stirred under H₂ atmosphere until 2 eq. of H₂ were absorbed. The catalyst was removed by filtration over Dicalite and the solvent was evaporated. Yield: 14.3 g of intermediate 51 (94.3 %).

References:

WO2009/16132,2009,A1 Location in patent:Page/Page column 69