tert-butyl 3-aminopropyl(isopropyl)carbamate synthesis
- Product Name:tert-butyl 3-aminopropyl(isopropyl)carbamate
- CAS Number:1111236-12-4
- Molecular formula:C11H24N2O2
- Molecular Weight:216.32
1111236-11-3
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1111236-12-4
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Yield:1111236-12-4 94.3%
Reaction Conditions:
with hydrogen;palladium 10% on activated carbon in methanol at 20;
Steps:
A.A17.c
c) Preparation of intermediate 51; Pd/C 10 % (2.5 g) was suspended in MeOH (125 ml). Intermediate 50 (27.8 g, 0.0700 mol) in MeOH (125 ml) was added (under N2 flow). The reaction mixture was stirred under H2 atmosphere until 2 eq. of H2 were absorbed. The catalyst was removed by filtration over Dicalite and the solvent was evaporated. Yield: 14.3 g of intermediate 51 (94.3 %).
References:
WO2009/16132,2009,A1 Location in patent:Page/Page column 69